In his sophomore season at ASU (2006–07), Pendergraph grabbed a career-high 19 rebounds in a 52–36 victory over Colgate on December 19, 2006. On January 2, 2009, as a senior (2008–09), he scored a career-high 31 points, along with a game-high 11 rebounds, in a 90–60 win over Stanford. Twenty-one of those points were tallied in the first half.
He signed a contract with the Portland Trail Blazers on September 8, 2009. His first game in the NBA came with the Blazers on December 22, 2009, against the Dallas Mavericks, in which he scored only two (2) points in 4 minutes of playing time.
Pendergraph scored a career-high 23 points on the last regular season game of the 2009–10 NBA season on April 14, 2010, against the Golden State Warriors. He was waived by the Trail Blazers prior to the start of the 2010 season after suffering a season-ending knee injury during a pre-season game against the Utah Jazz.
He was signed by the Indiana Pacers for the 2011–12 season. Before the start of the season he was sidelined with a mild sprain in his knee, suffered when he injured it during a December 10, 2011 practice. Pendergraph got his first start for the Indiana Pacers on April 23, 2012. In 18 minutes of play he scored 10 points with 7 rebounds, 1 assist and 2 blocks.
Pendergraph was ejected from Game 7 of the 2013 Eastern Conference Finals by referee Ken Mauer after a shoving match with Miami Heat guard Norris Cole, who was also ejected in the fourth quarter. Flo Rida's manager was also ejected after an ongoing verbal spat with Pendergraph.
NBA career statistics
|GP||Games played||GS||Games started||MPG||Minutes per game|
|FG%||Field goal percentage||3P%||3-point field goal percentage||FT%||Free throw percentage|
|RPG||Rebounds per game||APG||Assists per game||SPG||Steals per game|
|BPG||Blocks per game||PPG||Points per game||Bold||Career high|