De Colo was born in Sainte-Catherine-lès-Arras, France and attended Lycée Fernand Renaudeau in Cholet
De Colo made his professional debut during the 2006–07 season with the French Pro A club Cholet Basket. Under supervision of head coach Erman Kunter, he helped the team win the 2008 Semaine des As, and reach the finals of the 2008 French Cup and of the 2009 Eurochallenge.
He was drafted with the 53rd pick by the NBA club the San Antonio Spurs in the 2009 NBA Draft. He then moved to the Spanish ACB League club Valencia in 2009. He won the 2010 Eurocup title.
In July 2012, De Colo decided to leave Valencia, in order to play in the NBA. On July 13, 2012, De Colo signed a two-year deal with the San Antonio Spurs. The Spurs assigned him to the D-League's Austin Toros several times during the 2012–13 season.
|GP||Games played||GS||Games started||MPG||Minutes per game|
|FG%||Field goal percentage||3P%||3-point field goal percentage||FT%||Free throw percentage|
|RPG||Rebounds per game||APG||Assists per game||SPG||Steals per game|
|BPG||Blocks per game||PPG||Points per game||Bold||Career high|
NBA regular season
|2010–11||Power Electronics Valencia||19||19||21.5||.335||.276||.957||2.6||1.6||1.4||.2||10.1||8.2|